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与灵长类C型肿瘤病毒纯化包膜抗原发生反应的人抗体。

Human antibodies reactive with purified envelope antigens of primate type C tumor viruses.

作者信息

Kurth R, Mikschy U

出版信息

Proc Natl Acad Sci U S A. 1978 Nov;75(11):5692-6. doi: 10.1073/pnas.75.11.5692.

DOI:10.1073/pnas.75.11.5692
PMID:214794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393034/
Abstract

Human sera from healthy individuals have been shown to react with viral antigens in preparations of detergent-disrupted C type viruses from monkeys. In this report, it is demonstrated that (populations of) these human antibodies react with highly purified envelope glycoproteins of the simian sarcoma virus-simian sarcoma-associated virus complex and the Friend leukemia virus complex. Several immunological parameters influencing human antibody binding to C type tumor virus antigens have been characterized. These parameters indicate that human antibodies tend to bind to what is probably a subset of the antigenic determinants on the virus envelope antigens and that different human sera recognize the same antigenic determinants on the virus envelope antigens tested. The possible origin of these antibodies is discussed.

摘要

已证明来自健康个体的人血清能与经去污剂处理的猴C型病毒制剂中的病毒抗原发生反应。在本报告中，证明这些人抗体（群体）能与猿猴肉瘤病毒-猿猴肉瘤相关病毒复合物和弗瑞德白血病病毒复合物的高度纯化包膜糖蛋白发生反应。已对影响人抗体与C型肿瘤病毒抗原结合的几个免疫学参数进行了表征。这些参数表明，人抗体倾向于结合病毒包膜抗原上可能是抗原决定簇的一个子集，并且不同的人血清识别所测试的病毒包膜抗原上相同的抗原决定簇。还讨论了这些抗体可能的来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/393034/ec12e7906d64/pnas00021-0456-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/393034/ec12e7906d64/pnas00021-0456-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a30/393034/ec12e7906d64/pnas00021-0456-a.jpg

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本文引用的文献

1
Nucleic acid sequences of primate type C viruses in normal and neoplastic human tissues.正常和肿瘤性人类组织中灵长类C型病毒的核酸序列。
Nature. 1977 May 12;267(5607):175-7. doi: 10.1038/267175a0.
2
Brief communication: C-type particles in normal human placentas.简短通讯：正常人胎盘组织中的C型颗粒
J Natl Cancer Inst. 1973 Apr;50(4):1081-4. doi: 10.1093/jnci/50.4.1081.
3
Failure to detect, in human sera, antibodies cross-reactive with group-specific antigens of murine leukemia virus.未能在人血清中检测到与鼠白血病病毒群特异性抗原发生交叉反应的抗体。
RNA肿瘤病毒、癌基因及其在人类致癌过程中的可能作用。
Klin Wochenschr. 1983 Dec 15;61(24):1217-31. doi: 10.1007/BF01540470.
4
Heterophile binding of human antibodies to glycoproteins of retroviruses.
Br J Cancer. 1981 Apr;43(4):517-25. doi: 10.1038/bjc.1981.74.
5
Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures.人类抗体对肿瘤病毒糖蛋白的特异性：针对碳水化合物结构的天然抗体对抗原的识别。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1622-6. doi: 10.1073/pnas.77.3.1622.
6
HEL-12 virus: general considerations.HEL-12病毒：一般考虑因素。
Surv Immunol Res. 1983;2(1):12-24. doi: 10.1007/BF02918392.
7
Human leukemia viruses? RNA tumor viruses, human malignancies, and concepts of viral carcinogenesis.人类白血病病毒？RNA肿瘤病毒、人类恶性肿瘤与病毒致癌的概念。
Blut. 1980 Oct;41(4):247-56. doi: 10.1007/BF01020525.
8
Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus.人类拥有能够识别肿瘤病毒糖蛋白的抗体：证明这些抗体是因糖蛋白的细胞修饰而形成，而非接触病毒的结果。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1617-21. doi: 10.1073/pnas.77.3.1617.
J Natl Cancer Inst. 1974 May;52(5):1409-13. doi: 10.1093/jnci/52.5.1409.
4
A survey of cats and humans for prevalence of feline leukemia-sarcoma virus neutralizing serum antibodies.一项关于猫和人类中猫白血病-肉瘤病毒中和血清抗体流行情况的调查。
Proc Soc Exp Biol Med. 1974 Feb;145(2):560-4. doi: 10.3181/00379727-145-37851.
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7
A proposed nomenclature for the virion proteins of oncogenic RNA viruses.一种关于致癌RNA病毒病毒粒子蛋白的拟用命名法。
Virology. 1974 Aug;60(2):595-600. doi: 10.1016/0042-6822(74)90356-0.
8
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9
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Nature. 1973 Jul 27;244(5413):206-9. doi: 10.1038/244206a0.