二萜生物碱对A172人恶性细胞生长的抑制作用。
Inhibitory effects of diterpenoid alkaloids on the growth of A172 human malignant cells.
作者信息
Wada Koji, Hazawa Masaharu, Takahashi Kenji, Mori Takao, Kawahara Norio, Kashiwakura Ikuo
机构信息
School of Pharmacy, Hokkaido Pharmaceutical University, Otaru, Japan.
出版信息
J Nat Prod. 2007 Dec;70(12):1854-8. doi: 10.1021/np070270w. Epub 2007 Nov 29.
The cytotoxicity against A172 human malignant glioma cells was examined for 14 alkaloids from the roots of Aconitum yesoense var. macroyesoense and of Aconitum japonicum and from the seeds of Delphinium elatum as well as for 25 semisynthetic derivatives. The major alkaloid constituents of A. yesoense var. macroyesoense, kobusine (2) and pseudokobusine (3), a minor alkaloid constituent of A. japonicum, aljesaconitine A (5), and six alkaloid derivatives, N-deethyldelcosine (10), N-deethyldelsoline (11), 12-benzoylluciculine (18), 12-anisoylluciculine (19), 6,11-dibenzoylpseudokobusine (28), and 6-veratroylpseudokobusine (29), had only very weak activity. Four acylated alkaloid derivatives, 12-acetylluciculine (23), 11-veratroylpseudokobusine (30), 11-(m-trifluoromethylbenzoyl)pseudokobusine (32), and 11-(m-trifluoromethylbenzoyl)kobusine (39), exhibited more potent activity, while pseudokobusine 11-cinnamoate (31), 11-anisoate (33), and 11-p-nitrobenzoate (34) were found to be the most potent cytotoxic agents.
对来自大叶乌头（Aconitum yesoense var. macroyesoense）根、日本乌头（Aconitum japonicum）根以及高飞燕草（Delphinium elatum）种子中的14种生物碱和25种半合成衍生物，检测了它们对A172人恶性胶质瘤细胞的细胞毒性。大叶乌头的主要生物碱成分，牛扁碱（2）和伪牛扁碱（3），日本乌头的一种次要生物碱成分，阿杰乌头碱A（5），以及六种生物碱衍生物，N - 去乙基脱氢乌头碱（10）、N - 去乙基乌头碱（11）、12 - 苯甲酰基光翠雀碱（18）、12 - 茴香酰基光翠雀碱（19）、6,11 - 二苯甲酰基伪牛扁碱（28）和6 - 藜芦酰基伪牛扁碱（29），活性非常弱。四种酰化生物碱衍生物，12 - 乙酰基光翠雀碱（23）、11 - 藜芦酰基伪牛扁碱（30）、11 - （间三氟甲基苯甲酰基）伪牛扁碱（32）和11 - （间三氟甲基苯甲酰基）牛扁碱（39），表现出更强的活性，而伪牛扁碱11 - 肉桂酸酯（31）、11 - 茴香酸酯（33）和11 - 对硝基苯甲酸酯（34）被发现是最有效的细胞毒性剂。
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