舟形乌头碱A - C：来自舟形乌头的新二萜生物碱及其细胞毒性活性。
Navicularines A-C: New diterpenoid alkaloids from Aconitum naviculare and their cytotoxic activities.
作者信息
He Jiang-Bo, Luan Jie, Lv Xiao-Man, Rui Dan-Yun, Tao Jian, Wang Bo, Niu Yan-Feng, Ju Hong-Ping
机构信息
Kunming Key Laboratory of Respiratory Disease, Kunming University, Kunming 650214, PR China.
Yun Center for Disease Prevention and Control, Kunming 650022, PR China.
出版信息
Fitoterapia. 2017 Jul;120:142-145. doi: 10.1016/j.fitote.2017.06.008. Epub 2017 Jun 11.
Three new bisditerpenoid alkaloids, navicularines A-C (1-3), and three known ones (4-6), were isolated from the ground parts of Aconitum naviculare. Their structures were elucidated by spectroscopic methods. All the new compounds were tested against five cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480). It was found that navicularine B exhibited certain cytotoxic activities in vitro, with IC values of 13.50, 18.52, 17.22, 11.18, and 16.36μM, respectively.
从船形乌头的地上部分分离得到了三种新的双二萜生物碱，船形乌头碱A - C（1 - 3）以及三种已知生物碱（4 - 6）。通过光谱方法阐明了它们的结构。所有新化合物均针对五种细胞系（HL - 60、SMMC - 7721、A - 549、MCF - 7、SW480）进行了测试。结果发现，船形乌头碱B在体外表现出一定的细胞毒性活性，其IC值分别为13.50、18.52、17.22、11.18和16.36μM。
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