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Aryloxy acetic acid diuretics with uricosuric activity. I. Polycyclic aryloxy acetic acids.

作者信息

Kitagawa M, Mimura T, Tanaka M

机构信息

Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Sep;39(9):2400-7. doi: 10.1248/cpb.39.2400.

DOI:10.1248/cpb.39.2400
PMID:1804555
Abstract

In order to obtain lead compounds for uricosuric diuretics, various polycyclic aryloxy acetic acids [isoindole derivative (7), quinazoline derivative (15), benzopyran derivative (20), xanthone derivative (24), benzofuran derivative (30) and indene derivative (36)] were prepared. These compounds were evaluated for diuretic activity in rats, uricosuric activity in rats and antihypertensive activity in 11-deoxycorticosterone acetate (DOCA)/salt hypertensive rats. Among the compounds, 20 showed potent diuretic, uricosuric and moderate antihypertensive activities. Therefore, we selected 20 as a lead compound for development of new uricosuric diuretics.

摘要

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