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Studies on uricosuric diuretics. I. Syntheses and activities of xanthonyloxyacetic acids and dihydrofuroxanthone-2-carboxylic acids.

作者信息

Sato H, Dan T, Onuma E, Tanaka H, Koga H

机构信息

Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd,. Shizuoka, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1990 May;38(5):1266-77. doi: 10.1248/cpb.38.1266.

DOI:10.1248/cpb.38.1266
PMID:2393951
Abstract

A series of substituted xanthonyloxyacetic acids (5 and 6), 1,2-dihydrofuro[2,3-c]xanthone-2-carboxylic acids (7) and 2,3-dihydrofuro[3,2-b]xanthone-2-carboxylic acids (8) were synthesized and tested for diuretic and uricosuric activities in rats. Most of the xanthon-3-yloxyacetic acids (5) and 7 showed potent diuretic activities, while 8 had lower activities. Uricosuric activities were found in 5c, 5f, 5k, 5m, 5o, 5p, 5r, 7m, 7p and 8q.

摘要

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