五聚体蛋白3在慢性心力衰竭患者中的预后价值。

Prognostic value of pentraxin 3 in patients with chronic heart failure.

作者信息

Kotooka Norihiko, Inoue Teruo, Aoki Shigehisa, Anan Mayumi, Komoda Hiroshi, Node Koichi

机构信息

Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan.

出版信息

Int J Cardiol. 2008 Oct 30;130(1):19-22. doi: 10.1016/j.ijcard.2007.07.168. Epub 2007 Nov 28.

DOI:10.1016/j.ijcard.2007.07.168

PMID:18045709

Abstract

BACKGROUND

A long pentraxin, PTX3, is produced by vascular cells or inflammatory cells and released into the circulation, possibly reflecting local inflammation in the cardiovascular system.

AIM

This study was designed to assess the clinical significance of plasma pentraxin 3 (PTX3) levels in chronic heart failure (CHF).

METHODS

We measured plasma PTX3 levels in 37 patients with non-ischemic CHF (dilated cardiomyopathy) using enzyme-linked immunosorbent assay (ELISA) methods.

RESULTS

The plasma PTX3 levels were higher in CHF patients than in healthy subjects (P=0.001), and the CHF patients in the highest tertile of plasma PTX3 levels had more cardiac events than the patients in the lowest tertile (42% vs. 0%, P=0.02). Multivariate regression analysis showed that PTX3 was the most significant predictor of cardiac events (hazard ratio 1.912 for each increase in PTX3 of 1 ng/ml, P=0.019, 95% CI 1.114-3.282). In addition, PTX3 was strikingly expressed in human myocardial cells obtained from a biopsy specimen in a patient.

CONCLUSION

Plasma PTX3 levels might be a potentially useful biomarker to predict prognosis as well as to detect inflammatory status in patients with CHF.

摘要

背景

长链五聚体蛋白3（PTX3）由血管细胞或炎症细胞产生并释放到循环系统中，可能反映心血管系统的局部炎症。

目的

本研究旨在评估慢性心力衰竭（CHF）患者血浆五聚体蛋白3（PTX3）水平的临床意义。

方法

我们采用酶联免疫吸附测定（ELISA）法测量了37例非缺血性CHF（扩张型心肌病）患者的血浆PTX3水平。

结果

CHF患者的血浆PTX3水平高于健康受试者（P = 0.001），血浆PTX3水平处于最高三分位数的CHF患者发生心脏事件的比例高于最低三分位数的患者（42% 对0%，P = 0.02）。多变量回归分析显示，PTX3是心脏事件最显著的预测因子（PTX3每增加1 ng/ml，风险比为1.912，P = 0.019，95%可信区间为1.114 - 3.282）。此外，在一名患者活检标本中获取的人心肌细胞中，PTX3表达显著。