Dönitz Jürgen, Goemann Björn, Lizé Muriel, Michael Holger, Sasse Nicole, Wingender Edgar, Potapov Anatolij P
Department of Bioinformatics, University of Göttingen/Medical School, D-37077 Göttingen.
Nucleic Acids Res. 2008 Jan;36(Database issue):D689-94. doi: 10.1093/nar/gkm940. Epub 2007 Nov 27.
EndoNet is an information resource about intercellular regulatory communication. It provides information about hormones, hormone receptors, the sources (i.e. cells, tissues and organs) where the hormones are synthesized and secreted, and where the respective receptors are expressed. The database focuses on the regulatory relations between them. An elementary communication is displayed as a causal link from a cell that secretes a particular hormone to those cells which express the corresponding hormone receptor and respond to the hormone. Whenever expression, synthesis and/or secretion of another hormone are part of this response, it renders the corresponding cell an internal node of the resulting network. This intercellular communication network coordinates the function of different organs. Therefore, the database covers the hierarchy of cellular organization of tissues and organs as it has been modeled in the Cytomer ontology, which has now been directly embedded into EndoNet. The user can query the database; the results can be used to visualize the intercellular information flow. A newly implemented hormone classification enables to browse the database and may be used as alternative entry point. EndoNet is accessible at: http://endonet.bioinf.med.uni-goettingen.de/.
EndoNet是一个关于细胞间调节通讯的信息资源库。它提供有关激素、激素受体、激素合成和分泌的来源（即细胞、组织和器官）以及相应受体表达位置的信息。该数据库专注于它们之间的调节关系。一种基本通讯被显示为从分泌特定激素的细胞到那些表达相应激素受体并对该激素作出反应的细胞之间的因果联系。每当另一种激素的表达、合成和/或分泌是这种反应的一部分时，它就使相应的细胞成为所得网络的一个内部节点。这种细胞间通讯网络协调不同器官的功能。因此，该数据库涵盖了组织和器官的细胞组织层次结构，这是按照细胞本体论进行建模的，而细胞本体论现已直接嵌入EndoNet中。用户可以查询该数据库；结果可用于可视化细胞间信息流。新实施的激素分类功能使人们能够浏览数据库，并且可作为替代入口点使用。可通过以下网址访问EndoNet：http://endonet.bioinf.med.uni-goettingen.de/ 。
