Wingender Edgar, Hogan Jennifer, Schacherer Frank, Potapov Anatolij P, Kel-Margoulis Olga
BIOBASE GmbH, Wolfenbüttel, Germany.
In Silico Biol. 2007;7(2 Suppl):S17-25.
The HumanPSD database on the complete proteomes of human, mouse and rat has been integrated with the databases TRANSFAC on gene regulation and TRANSPATH on signal transduction to provide a comprehensive systems biological platform for these organisms. As a next step, integration with PathoDB and PathoSign on pathologically relevant mutations is planned together with an extension beyond the limits of the individual cell, towards intercellular networks, by integrating the database EndoNet on hormonal networks as well. The overall aim is to come up with a platform that is suitable to provide knowledge for systems pathology, i. e. a system-wide modeling of pathological states and their development.
关于人类、小鼠和大鼠完整蛋白质组的HumanPSD数据库已与基因调控数据库TRANSFAC和信号转导数据库TRANSPATH整合，为这些生物体提供了一个全面的系统生物学平台。下一步计划将其与PathoDB和PathoSign整合，后者涉及病理相关突变，同时通过整合激素网络数据库EndoNet，将范围扩展到单个细胞之外，建立细胞间网络。总体目标是打造一个适合为系统病理学提供知识的平台，即对病理状态及其发展进行全系统建模。
