Philiastides Marios G, Sajda Paul
Laboratory for Intelligent Imaging and Neural Computing, Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
J Neurosci. 2007 Nov 28;27(48):13082-91. doi: 10.1523/JNEUROSCI.3540-07.2007.
Single-unit and multiunit recordings in primates have already established that decision making involves at least two general stages of neural processing: representation of evidence from early sensory areas and accumulation of evidence to a decision threshold from decision-related regions. However, the relay of information from early sensory to decision areas, such that the accumulation process is instigated, is not well understood. Using a cued paradigm and single-trial analysis of electroencephalography (EEG), we previously reported on temporally specific components related to perceptual decision making. Here, we use information derived from our previous EEG recordings to inform the analysis of fMRI data collected for the same behavioral task to ascertain the cortical origins of each of these EEG components. We demonstrate that a cascade of events associated with perceptual decision making takes place in a highly distributed neural network. Of particular importance is an activation in the lateral occipital complex implicating perceptual persistence as a mechanism by which object decision making in the human brain is instigated.
在灵长类动物中进行的单神经元和多神经元记录已经证实，决策至少涉及神经处理的两个一般阶段：早期感觉区域对证据的表征以及决策相关区域将证据积累到决策阈值。然而，从早期感觉区域到决策区域的信息传递（正是这种传递引发了积累过程）还没有得到很好的理解。我们之前使用线索范式和脑电图（EEG）的单次试验分析，报告了与感知决策相关的时间特异性成分。在这里，我们利用先前EEG记录中获得的信息，为同一行为任务收集的功能磁共振成像（fMRI）数据的分析提供信息，以确定这些EEG成分各自的皮层起源。我们证明，与感知决策相关的一系列事件发生在一个高度分布式的神经网络中。特别重要的是枕外侧复合体的激活，这意味着感知持续性是人类大脑中物体决策启动的一种机制。
