Moĭbenko A A, Bulakh V N, Grabovskiĭ L A, Bakumenko L N
Farmakol Toksikol. 1991 Nov-Dec;54(6):23-5.
The preliminary inhibition of prostanoid biosynthesis by indomethacin (10 mg/kg, intravenously) strongly changes the typical anaphylactic shock reaction produced by the intracoronary injection of the challenging dose of the antigen in the dogs sensitized with normal horse serum. A rapid fall of blood pressure and cardiac output at the first stage of the anaphylactic reaction is sharply diminished, the reaction of the coronary vessels is inversed. Instead of dilatation, vasoconstriction occurred increasing with the repeated administration of the antigen. The data obtained suggest that the initial hypotension under anaphylactic shock is due to prostanoid production while the coronary spasm is the result of lipoxygenase activation.
消炎痛（10毫克/千克，静脉注射）对前列腺素生物合成的初步抑制作用，极大地改变了在用正常马血清致敏的犬中，冠状动脉内注射激发剂量抗原所产生的典型过敏休克反应。过敏反应第一阶段血压和心输出量的快速下降明显减轻，冠状动脉血管反应发生逆转。不再是扩张，而是随着抗原的重复给药出现血管收缩增加。所获得的数据表明，过敏休克时最初的低血压是由于前列腺素的产生，而冠状动脉痉挛是脂氧合酶激活的结果。
