Moĭbenko A A, Kolchin Iu N, Bulakh V N, Sorochinskiĭ A E
Biull Eksp Biol Med. 1991 Feb;111(2):120-3.
The effects of intracoronary LTC4 administration have been studied in narcotized dogs with an intact chest. LTC4 in doses of 0.5-40 micrograms produced a dose-dependent decrease in coronary flow, inhibition of myocardial contractility and disturbance of cardiac rhythm. A decrease in myocardial contractility was shown to take place before the signs of myocardial ischemia had appeared that could not be entirely due to the decrease in coronary blood flow. Ultrastructural changes in the endothelium of the coronary vessels have also been observed under the action of LTC4.
已在开胸麻醉犬身上研究了冠状动脉内给予白三烯C4（LTC4）的作用。剂量为0.5 - 40微克的LTC4可使冠状动脉血流量呈剂量依赖性减少、心肌收缩力受到抑制并出现心律失常。结果表明，在心肌缺血迹象出现之前心肌收缩力就已下降，而这不可能完全归因于冠状动脉血流量的减少。在LTC4的作用下，还观察到了冠状动脉血管内皮的超微结构变化。
