Wilson Ian
Department of General Practice, University of Adelaide, SA, Australia.
Int J Chron Obstruct Pulmon Dis. 2006;1(1):61-4. doi: 10.2147/copd.2006.1.1.61.
This paper explores the recent literature surrounding comorbid depression and COPD. The literature reveals a high prevalence of depression in patients with COPD and some evidence that the depression is a result of the disease. The literature highlights the negative impact of depression on quality of life and a possible impact on mortality. Depression also negatively impacts on compliance and smoking cessation. Treatment of depression in COPD, particularly by cognitive behavioral therapy, has positive impact on quality of life. Tricyclic antidepressants have a positive impact on mood and COPD, but side effects limit their use. The advent of the new antidepressants may improve acceptability and outcomes, but the research is yet to be undertaken. Physical rehabilitation may have a positive impact on mood. This paper highlights the difficulty in screening for depression in patients with COPD due to the overlap of symptoms between the two diseases. Despite the difficulties, it is important to recognize and treat depression in patients with COPD because of the significant likelihood of improvement in quality of life.
本文探讨了近期围绕合并抑郁症和慢性阻塞性肺疾病（COPD）的文献。文献显示COPD患者中抑郁症的患病率很高，并有一些证据表明抑郁症是该疾病的结果。文献强调了抑郁症对生活质量的负面影响以及对死亡率可能产生的影响。抑郁症还对依从性和戒烟产生负面影响。COPD患者抑郁症的治疗，尤其是通过认知行为疗法，对生活质量有积极影响。三环类抗抑郁药对情绪和COPD有积极影响，但副作用限制了它们的使用。新型抗抑郁药的出现可能会提高可接受性和治疗效果，但相关研究尚未开展。身体康复可能对情绪有积极影响。本文强调了由于两种疾病症状重叠，在COPD患者中筛查抑郁症存在困难。尽管存在困难，但认识并治疗COPD患者的抑郁症很重要，因为生活质量有显著改善的可能性。
