Department of Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan.
Nutrients. 2021 Nov 12;13(11):4055. doi: 10.3390/nu13114055.
The global pandemic of obesity and the increasing incidence of chronic respiratory diseases are growing health concerns. The association between obesity and pulmonary function is uncertain. Therefore, this study aimed to explore associations between changes in lung function and obesity-related indices in a large longitudinal study. A total of 9059 participants with no personal histories of asthma, smoking, bronchitis, or emphysema were enrolled from the Taiwan Biobank and followed for 4 years. Lung function was assessed using spirometry measurements including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Changes in FEV1/FVC (∆FEV1/FVC) between baseline and follow-up were calculated. The following obesity-related indices were studied: lipid accumulation product (LAP), body roundness index (BRI), conicity index (CI), body adiposity index (BAI), abdominal volume index (AVI), body mass index (BMI), waist-hip ratio (WHR), and waist-to-height ratio (WHtR). In multivariable analysis, the subjects with high BMI ( < 0.001), WHR ( < 0.001), WHtR ( < 0.001), LAP ( = 0.002), BRI ( < 0.001), CI ( = 0.005), BAI ( < 0.001), and AVI ( < 0.001) were significantly associated with a high baseline FEV1/FVC. After 4 years of follow-up, the subjects with high BMI ( < 0.001), WHR ( < 0.001), WHtR ( < 0.001), LAP ( = 0.001), BRI ( < 0.001), CI ( = 0.002), BAI ( < 0.001), and AVI ( < 0.001) were significantly associated with a low △FEV1/FVC. High obesity-related index values were associated with better baseline lung function and a rapid decrease in lung function at follow-up.
肥胖症的全球流行和慢性呼吸道疾病发病率的不断上升，是日益严重的健康问题。肥胖症与肺功能之间的关系尚不确定。因此，本研究旨在通过一项大型纵向研究，探讨肺功能变化与肥胖相关指标之间的关系。这项研究共纳入了 9059 名无哮喘、吸烟、支气管炎或肺气肿个人病史的参与者，他们来自台湾生物银行，并随访了 4 年。使用肺活量计测量包括 1 秒用力呼气量（FEV1）和用力肺活量（FVC）在内的肺功能。计算了从基线到随访时 FEV1/FVC 的变化（∆FEV1/FVC）。研究了以下肥胖相关指标：脂肪堆积产物（LAP）、体圆度指数（BRI）、锥度指数（CI）、身体脂肪指数（BAI）、腹部容量指数（AVI）、体重指数（BMI）、腰围臀围比（WHR）和腰高比（WHtR）。在多变量分析中，高 BMI（<0.001）、WHR（<0.001）、WHtR（<0.001）、LAP（=0.002）、BRI（<0.001）、CI（=0.005）、BAI（<0.001）和 AVI（<0.001）的受试者，其基线 FEV1/FVC 较高。经过 4 年的随访，高 BMI（<0.001）、WHR（<0.001）、WHtR（<0.001）、LAP（=0.001）、BRI（<0.001）、CI（=0.002）、BAI（<0.001）和 AVI（<0.001）的受试者，其△FEV1/FVC 较低。高肥胖相关指数值与较好的基线肺功能和随访时肺功能快速下降有关。
