Son You-Hwan, Park Man, Kim Sang Tae, Choy Jin-Ho
Center for Intelligent Nano-Bio Materials (CINBM), Division of Nanoscience and Department of Chemistry, Ewha Womans University, Seoul 120-750, Korea.
J Nanosci Nanotechnol. 2007 Nov;7(11):3819-22. doi: 10.1166/jnn.2007.037.
Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C16,E20) and C2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C16E20/C2-ceramide). TEM and N2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C2-ceramides. However, when the weight ratio of C16E20/C2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.
介孔二氧化硅材料是通过一种新型的混合胶束模板法制备的，该方法采用了烷基聚环氧乙烷（C16,E20）和C2-神经酰胺。X射线衍射图谱清楚地表明，在混合胶束模板的作用下，直至重量比达到3/1（C16E20/C2-神经酰胺）时介孔二氧化硅形成。透射电子显微镜（TEM）和N2吸附等温线分析表明，即使包裹了C2-神经酰胺，介孔结构仍得以保持。然而，当C16E20/C2-神经酰胺的重量比超过2/2时，观察到孔结构的有序性降低且不规则。根据对MCF-7、HOS和HepG2等癌细胞的体外实验，同时包裹的C2-神经酰胺显示出凋亡现象。因此，目前的结果可为介孔材料作为药物递送系统提供一种新方法。
