Maselli M A, Messa C, Pezzolla F, Riezzo G, Caruso M L, Di Leo A
Laboratory of Experimental Physiopathology, Istituto di Ricovero e Cura a Carattere Scientifico S. de Bellis, Castellana, Italia.
Digestion. 1991;50(1):22-7. doi: 10.1159/000200736.
Twenty-five gallbladders were studied in vitro. Sixteen had radiolucent gallstones and 9 had radiopaque gallstones. The radiolucent gallstones had a cholesterol content of 94.17 +/- 3.76% and the radiopaque gallstones had a cholesterol content of 56.6 +/- 4.46%. Half the maximal response (ED50) to cholecystokinin octapeptide (CCK-OP) and to carbachol in strips from patients with radiolucent gallstones was 0.8 +/- 0.15 and 27.01 +/- 3.74 x 10(-7) M, respectively. In strips from patients with radiopaque gallstones, the ED50 was 0.4 +/- 0.08 and 14.92 +/- 3.07 x 10(-7) M, respectively. The ED50 values to CCK-OP and carbachol were greater in strips from specimens with radiolucent gallstones than in strips from specimens with radiopaque gallstones (p less than 0.05). There was no significant difference in the maximal contractile response of the two groups. It can be concluded that gallbladder sensitivity to CCK-OP and carbachol can be modified in relation to differences in the cholesterol and calcium content of the stones.
对25个胆囊进行了体外研究。16个有透X线的胆结石，9个有不透X线的胆结石。透X线胆结石的胆固醇含量为94.17±3.76%，不透X线胆结石的胆固醇含量为56.6±4.46%。来自有透X线胆结石患者的胆囊条对八肽胆囊收缩素（CCK-OP）和卡巴胆碱的半数最大反应（ED50）分别为0.8±0.15和27.01±3.74×10⁻⁷M。来自有不透X线胆结石患者的胆囊条，其ED50分别为0.4±0.08和14.92±3.07×10⁻⁷M。有透X线胆结石标本的胆囊条对CCK-OP和卡巴胆碱的ED50值高于有不透X线胆结石标本的胆囊条（p<0.05）。两组的最大收缩反应无显著差异。可以得出结论，胆囊对CCK-OP和卡巴胆碱的敏感性可因结石胆固醇和钙含量的差异而改变。
