An efficient synthesis of chiral beta-hydroxy sulfones via ru-catalyzed enantioselective hydrogenation in the presence of iodine.

作者信息

Wan Xiaobing, Meng Qinghua, Zhang Hongwei, Sun Yanhui, Fan Weizheng, Zhang Zhaoguo

机构信息

School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China.

出版信息

Org Lett. 2007 Dec 20;9(26):5613-6. doi: 10.1021/ol702565x. Epub 2007 Nov 30.

Ru-SUNPHOS catalyzed asymmetric hydrogenation of a variety of sulfonyl ketones (R = alkyl, aryl) in the presence of iodine gave enantioenriched hydroxyl sulfones with good catalytic efficiency. Further investigation revealed that the in situ generated anhydrous HI is the operating additive.