用于比较受检测限影响的生物标志物鉴别能力的最大似然比检验。
Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection.
作者信息
Vexler Albert, Liu Aiyi, Eliseeva Ekaterina, Schisterman Enrique F
机构信息
Division of Epidemiology, Statistics and Prevention Research, NICHD, NIH, Rockville, Maryland 20852, U.S.A.
Department of Biostatistics, The State University of New York, Farber Hall, Buffalo, New York 14214, U.S.A.
出版信息
Biometrics. 2008 Sep;64(3):895-903. doi: 10.1111/j.1541-0420.2007.00941.x. Epub 2007 Nov 19.
Abstract
In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.
摘要
在本文中，我们考虑比较诊断生物标志物的相关接收者操作特征（ROC）曲线下的面积，这些生物标志物的测量受到检测限（LOD）的影响，检测限是流行病学研究中仪器灵敏度导致的测量误差来源。我们提出并检验了具有易于通过经典最大似然方法获得的操作特征的似然比检验。
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