Raimondi Francesco, Migliaro Fiorella, Capasso Letizia, Ausanio Gaetano, Bisceglia Massimo, Giliberti Paolo, Messina Francesco, Salvia Gennaro, Paludetto Roberto
Division of Neonatology, Department of Pediatrics, Università Federico II, Naples, Italy.
J Trop Pediatr. 2008 Jun;54(3):196-9. doi: 10.1093/tropej/fmm101. Epub 2007 Nov 29.
We have compared intravenous magnesium sulphate vs. inhaled nitric oxide in the therapy of moderate persistent pulmonary hypertension of the neonate. A retrospective collection of clinical data from 58 neonates was carried out in six neonatal intensive care units of Southern Italy sharing the same operational protocols. In our setting, both drugs were effective in treating moderate persistent pulmonary hypertension of the neonate but nitric oxide (NO) treatment resulted in much faster amelioration of oxygenation index, taken as a marker of the underlying condition. No significant difference was recorded in immediate or long-term complications. We conclude that, wherever NO facilities are not readily available, magnesium sulphate is a safe and cheaper alternative for first-line treatment of moderate persistent pulmonary hypertension of the neonate.
我们比较了静脉注射硫酸镁与吸入一氧化氮治疗新生儿中度持续性肺动脉高压的效果。在意大利南部六个采用相同操作方案的新生儿重症监护病房中，对58例新生儿的临床资料进行了回顾性收集。在我们的研究中，两种药物对治疗新生儿中度持续性肺动脉高压均有效，但以一氧化氮（NO）治疗可使作为潜在病情指标的氧合指数改善得更快。在即刻或长期并发症方面未记录到显著差异。我们得出结论，无论何时一氧化氮设备难以随时获取，硫酸镁都是治疗新生儿中度持续性肺动脉高压一线治疗的安全且更便宜的替代药物。
