儿童哮喘急性发作时延长硫酸镁（MgSO₄）输注的安全性和有效性
Safety and Effectiveness of Prolonged Magnesium Sulfate (MgSO ) Infusion for Asthma Exacerbation in Children.
作者信息
Awlad Thani Saif Sulaiman, Alkhan Atheer Ahmed, Al-Farsi Muzna Yahya, Al Kamzari Ahmed Mohammed
机构信息
Section of Pediatric Intensive Care, Child Health Department, The Royal Hospital, Muscat, Oman.
Child Health Department, The Royal Hospital, Muscat, Oman.
出版信息
J Pediatr Intensive Care. 2022 Feb 21;13(4):344-351. doi: 10.1055/s-0042-1742674. eCollection 2024 Dec.
The objective of this study was to assess the safety and describe treatment details of prolonged magnesium sulfate (MgSO ) infusion for children with asthma exacerbation. A retrospective cross-sectional study included children under 13 years of age who were admitted with asthma exacerbation and received at least 24 hours of MgSO infusion. One hundred children were included. No patients developed serious adverse events. The mean infusion duration was 74.2 hours. Eighty-nine percent recovered with no other bronchodilator infusions, and 94% did not require respiratory support escalation. Prolonged MgSO infusion is safe at a maximum dose of 30 mg/kg/h and may be beneficial for children with asthma exacerbation.
本研究的目的是评估硫酸镁（MgSO₄）长时间输注治疗哮喘急性发作儿童的安全性并描述治疗细节。一项回顾性横断面研究纳入了13岁以下因哮喘急性发作入院且接受至少24小时硫酸镁输注的儿童。共纳入100名儿童。无患者发生严重不良事件。平均输注时间为74.2小时。89%的患者在未使用其他支气管扩张剂输注的情况下康复，94%的患者不需要升级呼吸支持。硫酸镁最大剂量为30mg/kg/h时，长时间输注是安全的，可能对哮喘急性发作儿童有益。
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