Virk K J, Ganguly N K, Prasad R N, Dilawari J B, Mahajan R C
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Hyg Epidemiol Microbiol Immunol. 1991;35(4):419-27.
Very few studies have been carried out on the role of liver macrophages (Kupffer cells) during the course of hepatic amoebiasis. The kinetics of phagocytic activity of Kupffer cells and blood monocytes was studied in guinea pigs intra-mesenterically infested with Entamoeba histolytica. The phagocytic capacity of blood monocytes of normal animals was comparatively lower than Kupffer cells for both latex and haemolysin coated sheep red blood cells. Significant decline in phagocytic response of Kupffer cells and blood monocytes of infected animals was observed right from 2nd post infection day and it kept on decreasing with the progress of infection. Depression in phagocytic response of Kupffer cells and blood monocytes was more marked in those animals who had higher grades of pathological lesions. Hence, an inverse correlation was obtained between the phagocytic capacity and severity of amoebic lesions (P less than 0.01). The significance of depression in phagocytic response of Kupffer cells and blood monocytes may be responsible for the development of hepatic lesions.
关于肝巨噬细胞（库普弗细胞）在肝阿米巴病病程中的作用，所开展的研究非常少。在经肠系膜内感染溶组织内阿米巴的豚鼠中，研究了库普弗细胞和血液单核细胞的吞噬活性动力学。对于乳胶包被和溶血素包被的绵羊红细胞，正常动物血液单核细胞的吞噬能力相对低于库普弗细胞。从感染后第2天起，就观察到感染动物的库普弗细胞和血液单核细胞的吞噬反应显著下降，并且随着感染的进展持续降低。在那些具有较高等级病理病变的动物中，库普弗细胞和血液单核细胞的吞噬反应抑制更为明显。因此，在吞噬能力与阿米巴病变严重程度之间获得了负相关（P小于0.01）。库普弗细胞和血液单核细胞吞噬反应抑制的意义可能与肝脏病变的发生有关。
