Vogelgesang Antje, Grunwald Uwe, Langner Sönke, Jack Robert, Bröker Barbara M, Kessler Christof, Dressel Alexander
Stroke. 2008 Jan;39(1):237-41. doi: 10.1161/STROKEAHA.107.493635. Epub 2007 Nov 29.
Recent studies have attributed the increased infection vulnerability of patients with stroke to stroke-induced immunosuppression. We have therefore explored the immunological changes in patients with ischemic stroke.
Blood from 46 patients with stroke was analyzed by fluorescent-activated cell sorter to determine leukocyte subsets. To identify changes that represent clinically relevant immunosuppression, we compared patients who developed infection within 14 days after stroke with those who did not.
Stroke induced a dramatic and immediate loss of T-lymphocytes, most pronounced within 12 hours after stroke onset. Only patients with subsequent infection exhibited a delay in the recovery of CD4+ T-lymphocyte counts.
Our data suggest that a loss of CD4+ T cell function contributes to the stroke-induced immunosuppression. The CD4+ T cell count on the day after stroke may emerge as a predictive marker for poststroke infection allowing, early identification of patients at risk.
近期研究认为，中风患者感染易感性增加是由中风诱导的免疫抑制所致。因此，我们探讨了缺血性中风患者的免疫变化。
采用荧光激活细胞分选仪分析46例中风患者的血液，以确定白细胞亚群。为了识别代表临床相关免疫抑制的变化，我们比较了中风后14天内发生感染的患者和未发生感染的患者。
中风导致T淋巴细胞急剧且即刻减少，在中风发作后12小时内最为明显。只有随后发生感染的患者CD4 + T淋巴细胞计数恢复延迟。
我们的数据表明，CD4 + T细胞功能丧失导致了中风诱导的免疫抑制。中风后第一天的CD4 + T细胞计数可能成为中风后感染的预测标志物，从而能够早期识别有风险的患者。
