Gong Huanhuan, Li Zheng, Huang Guoqing, Mo Xiaoye
Department of Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Heliyon. 2024 May 29;10(11):e32171. doi: 10.1016/j.heliyon.2024.e32171. eCollection 2024 Jun 15.
Ischemic stroke is still one of the most serious medical conditions endangering human health worldwide. Current research on the mechanism of ischemic stroke focuses on the primary etiology as well as the subsequent inflammatory response and immune modulation. Recent research has revealed that peripheral blood cells and their components are crucial to the ensuing progression of ischemic stroke. However, it remains unclear whether blood cell elements are principally in charge of systemic inflammation or immunological regulation, or if their participation is beneficial or harmful to the development of ischemic stroke. In this review, we aim to describe the changes in peripheral blood cells and their corresponding parameters in ischemic stroke. Specifically, we elaborate on the role of each peripheral component in the inflammatory response or immunological modulation as well as their interactions. It has been suggested that more specific therapies aimed at targeting peripheral blood cell components and their role in inflammation or immunity are more favorable to the treatment of ischemic stroke.
缺血性中风仍然是全球范围内危害人类健康的最严重疾病之一。目前对缺血性中风机制的研究集中在主要病因以及随后的炎症反应和免疫调节上。最近的研究表明，外周血细胞及其成分对缺血性中风的后续进展至关重要。然而，血细胞成分是主要负责全身炎症还是免疫调节，或者它们的参与对缺血性中风的发展是有益还是有害，仍不清楚。在这篇综述中，我们旨在描述缺血性中风中外周血细胞及其相应参数的变化。具体来说，我们详细阐述了每个外周成分在炎症反应或免疫调节中的作用及其相互作用。有人提出，针对外周血细胞成分及其在炎症或免疫中的作用的更特异性疗法对缺血性中风的治疗更有利。
