Cintra D E, Ropelle E R, Pauli J R
Departamento de Clínica Médica, Faculdade de Ciencias Medicas da Universidade Estadual de Campinas, São Paulo, Brasil.
Rev Neurol. 2007;45(11):672-82.
Overweight and obesity present significant public health concerns because of the link with numerous chronic health conditions. During the last ten years, since the discovery of leptin, great advances were obtained in the characterization oh the hypothalamic mechanisms involved in the control of food intake and thermogenesis.
This review will present some the most recent findings in this field. It will be focused on the actions of leptin and insulin in the hypothalamus and will explore the hypothesis that hypothalamic resistance to the action of these hormones may play a key role in the development of obesity.
The physical activity is an important component on long-term weight control. The exercise markedly increased phosphorylation activity of several proteins involved in leptin and insulin signal transduction in the hypothalamus. Recently our laboratory showed that physical activity increase in sensitivity to leptin- and insulin-induced anorexia after enhances interleukin-6 production. These findings provide support for the hypothesis that the appetite-suppressive actions of exercise may be mediated by the hypothalamus.
超重和肥胖因与众多慢性健康状况相关而成为重大的公共卫生问题。在过去十年中，自瘦素被发现以来，在阐明参与食物摄入控制和产热的下丘脑机制方面取得了巨大进展。
本综述将介绍该领域的一些最新发现。它将聚焦于瘦素和胰岛素在下丘脑的作用，并探讨下丘脑对这些激素作用的抵抗可能在肥胖发展中起关键作用这一假说。
身体活动是长期体重控制的重要组成部分。运动显著增加了下丘脑参与瘦素和胰岛素信号转导的几种蛋白质的磷酸化活性。最近我们实验室表明，身体活动通过增强白细胞介素 - 6 的产生，提高了对瘦素和胰岛素诱导的厌食的敏感性。这些发现为运动的食欲抑制作用可能由下丘脑介导这一假说提供了支持。
