Richette Pascal, Ayoub Ghazi, Lahalle Sophie, Vicaut Eric, Badran Abdul-Monem, Joly Francisca, Messing Bernard, Bardin Thomas
Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Paris, France.
Arthritis Rheum. 2007 Dec 15;57(8):1496-501. doi: 10.1002/art.23106.
To determine an association between magnesium (Mg) depletion and chondrocalcinosis, which has been reported but not investigated in a cross-sectional study.
Prevalence of chondrocalcinosis was investigated in 144 individuals: 72 patients receiving home parenteral nutrition (HPN) compared with 72 age- and sex-matched controls. Presence of chondrocalcinosis was assessed by knee radiographs. Blood serum and globular Mg levels and 24-hour urinary Mg content were compared.
Mean +/- SD age for both patients and controls was 51 +/- 17 years, and 51% in both groups were women. Mean duration of HPN was 6.4 years. Prevalence of chondrocalcinosis was markedly higher in patients receiving HPN than controls (16.6% versus 2.7%; P = 0.006, odds ratio [OR] 7.0, 95% confidence interval [95% CI] 1.45-66.1). Mean +/- SD serum and globular Mg levels were significantly lower in patients than controls (serum: 0.75 +/- 0.09 mmoles/liter versus 0.81 +/- 0.08 mmoles/liter, P = 0.0006; globular Mg: 1.8 +/- 0.31 mmoles/liter versus 2.0 +/- 0.35 mmoles/liter, P = 0.0003). Twenty-four-hour urinary Mg level was lower in patients than controls (mean +/- SD 3.85 +/- 1.50 mmoles versus 5.37 +/- 3.71 mmoles; P = 0.001). Prevalence of chondrocalcinosis was significantly higher in patients with a low serum Mg level (OR 13.5, 95% CI 2.76-127.3, P < 0.0001), with a similarly high but not significant occurrence of chondrocalcinosis in patients with a low globular Mg level (OR 4.09, 95% CI 0.603-20.26, P = 0.08) and in patients with a low 24-hour urinary Mg level (OR 3.9, 95% CI 0.77-16.34, P = 0.05).
Long-lasting Mg depletion is strongly associated with chondrocalcinosis.
确定镁（Mg）缺乏与软骨钙质沉着症之间的关联，此前已有报道但尚未在横断面研究中进行调查。
对144人进行软骨钙质沉着症患病率调查：72例接受家庭肠外营养（HPN）的患者与72例年龄和性别匹配的对照组。通过膝关节X线片评估软骨钙质沉着症的存在情况。比较血清和球细胞镁水平以及24小时尿镁含量。
患者和对照组的平均年龄±标准差为51±17岁，两组中51%为女性。HPN的平均持续时间为6.4年。接受HPN的患者软骨钙质沉着症的患病率明显高于对照组（16.6%对2.7%；P = 0.006，优势比[OR]7.0，95%置信区间[95%CI]1.45 - 66.1）。患者的血清和球细胞镁水平的平均±标准差显著低于对照组（血清：0.75±0.09毫摩尔/升对0.81±0.08毫摩尔/升，P = 0.0006；球细胞镁：1.8±0.31毫摩尔/升对2.0±0.35毫摩尔/升，P = 0.0003）。患者的24小时尿镁水平低于对照组（平均±标准差3.85±1.50毫摩尔对5.37±3.71毫摩尔；P = 0.001）。血清镁水平低的患者软骨钙质沉着症的患病率显著更高（OR 13.5，95%CI 2.76 - 127.3，P < 0.0001），球细胞镁水平低的患者软骨钙质沉着症的发生率同样高但不显著（OR 4.09，95%CI 0.603 - 20.26，P = 0.08），24小时尿镁水平低的患者软骨钙质沉着症的发生率也高（OR 3.9，95%CI 0.77 - 16.34，P = 0.05）。
长期镁缺乏与软骨钙质沉着症密切相关。
