晶体疾病和高尿酸血症患者的合并症。
Comorbidities in patients with crystal diseases and hyperuricemia.
作者信息
Sattui Sebastian E, Singh Jasvinder A, Gaffo Angelo L
机构信息
Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama, Faculty Office Tower 813, 510 20th Street South, Birmingham, AL 35294, USA.
Medicine Service, Center for Surgical Medical Acute Care Research and Transitions (C-SMART), 700 19th Street South, Birmingham VA Medical Center, Birmingham, AL 35233, USA; Division of Clinical Immunology and Rheumatology, Department of Medicine, School of Medicine, University of Alabama, Faculty Office Tower 805B, 200 First Street South West, Rochester, MN 55905, USA; Department of Orthopedic Surgery, Mayo Clinic College of Medicine, Rochester, MN, USA.
出版信息
Rheum Dis Clin North Am. 2014 May;40(2):251-78. doi: 10.1016/j.rdc.2014.01.005. Epub 2014 Feb 19.
Crystal arthropathies are among the most common causes of painful inflammatory arthritis. Gout, the most common example, has been associated with cardiovascular and renal disease. In recent years, evidence for these associations and those involving other comorbidities, such as the metabolic syndrome, have emerged, and the importance of asymptomatic hyperuricemia has been established. In this review, an update on evidence, both experimental and clinical, is presented, and associations between hyperuricemia, gout, and several comorbidities are described. Causality regarding calcium pyrophosphate arthropathy and associated comorbidities is also reviewed.
晶体性关节病是引起疼痛性炎性关节炎的最常见原因之一。痛风是最常见的例子，它与心血管疾病和肾脏疾病有关。近年来，这些关联以及与其他合并症（如代谢综合征）相关的证据不断涌现，无症状高尿酸血症的重要性也已得到确认。在本综述中，我们介绍了实验和临床证据的最新情况，并描述了高尿酸血症、痛风与几种合并症之间的关联。我们还回顾了焦磷酸钙关节病及其相关合并症的因果关系。
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