Greenwald Iva
Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.
WormBook. 2005 Aug 8:1-16. doi: 10.1895/wormbook.1.10.1.
Receptors of the LIN-12/Notch family mediate cell-cell interactions during animal development, and aberrations in LIN-12/Notch signaling have been implicated in human disease. Studies in C. elegans have been instrumental in defining the basic features of the LIN-12/Notch pathway, the role of LIN-12/Notch proteins as receptors for intercellular signals, the mechanism of signal transduction, and the regulation of LIN-12/Notch signaling during cell fate decisions. This chapter is focused on detailing how the "awesome power of C. elegans genetics" has identified many core components and modulators of LIN-12/Notch activity.
LIN-12/Notch家族的受体在动物发育过程中介导细胞间相互作用，并且LIN-12/Notch信号传导异常与人类疾病有关。秀丽隐杆线虫的研究对于确定LIN-12/Notch信号通路的基本特征、LIN-12/Notch蛋白作为细胞间信号受体的作用、信号转导机制以及细胞命运决定过程中LIN-12/Notch信号传导的调节起到了重要作用。本章重点详述了秀丽隐杆线虫遗传学的“强大力量”是如何鉴定出LIN-12/Notch活性的许多核心成分和调节因子的。
