Lewis D S, Coelho A M, Jackson E M
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
Pediatr Res. 1991 Dec;30(6):534-40. doi: 10.1203/00006450-199112000-00007.
We tested the hypothesis that overfeeding with a high caloric (concentrated) formula increases growth without influencing adipocyte volume in preweaning infant baboons. Female infant baboons from three sires and 25 dams were fed either 67.5 kcal (normal formula) or 94.5 kcal (concentrated formula)/100 g Similac formula. Immediately before weaning (19 wk), adipocyte volume was measured in biopsied adipose tissue from omentum, flank, and popliteal depots. From birth until weaning, infants fed the concentrated formula consumed 20% more total calories, averaged 15% more calories/kg/wk, and gained 14% more weight than normally fed infants. Adipocyte volume differed significantly among different sites (omentum greater than popliteal greater than flank) and among different sire groups. Increased caloric intake alone did not increase adipocyte volume. There was a small but significant sire by infant formula interaction on adipocyte volume. When fed the concentrated formula, progeny from one sire had larger adipocytes than normally fed infants, whereas progeny from the other two sires had smaller adipocytes or adipocytes that were comparable to infants fed normal formula. Variability in adipocyte volume at 19 wk of age was best accounted for by maternal weight and sire group (omentum R2 = 0.334, p = 0.026; flank R2 = 0.532, p = 0.01; popliteal R2 = 0.482, p = 0.01) and not by caloric intake. These results suggest that the level of triglyceride deposition into adipocytes attained during preweaning growth is determined to a greater extent by genetic and other factors rather than caloric intake.
用高热量（浓缩）配方奶过度喂养会增加断奶前幼年狒狒的生长速度，而不影响脂肪细胞体积。来自3个父系和25个母系的雌性幼年狒狒，分别喂食每100克含67.5千卡（正常配方）或94.5千卡（浓缩配方）的Similac配方奶。在即将断奶时（19周龄），测量取自网膜、胁腹和腘窝脂肪库的活检脂肪组织中的脂肪细胞体积。从出生到断奶，喂食浓缩配方奶的幼狒比正常喂食的幼狒多摄入20%的总热量，平均每周每千克多摄入15%的热量，体重多增加14%。不同部位（网膜大于腘窝大于胁腹）和不同父系组之间的脂肪细胞体积存在显著差异。单纯热量摄入增加并不会增加脂肪细胞体积。在脂肪细胞体积方面，存在一个微小但显著的父系与婴儿配方奶的交互作用。喂食浓缩配方奶时，来自一个父系的后代脂肪细胞比正常喂食的幼狒大，而来自其他两个父系的后代脂肪细胞较小或与喂食正常配方奶的幼狒相当。19周龄时脂肪细胞体积的变异性，最好由母体体重和父系组来解释（网膜R2 = 0.334，p = 0.026；胁腹R2 = 0.532，p = 0.01；腘窝R2 = 0.482，p = 0.01），而非热量摄入。这些结果表明，断奶前生长过程中脂肪细胞内甘油三酯沉积的水平，在很大程度上是由遗传和其他因素决定的，而非热量摄入。
