Lewis D S, Bertrand H A, McMahan C A, McGill H C, Carey K D, Masoro E J
J Clin Invest. 1986 Oct;78(4):899-905. doi: 10.1172/JCI112678.
The hypothesis that preweaning nutrition influences adult fat cell number and adiposity was tested in baboons. Newborn baboons were fed Similac formulas with caloric densities of 40.5 kcal (underfed), 67.5 kcal (fed normally), and 94.5 kcal (overfed) per 100 g formula. From weaning (16 wk) until necropsy at 5 yr of age all baboons were fed the same diet. At necropsy, fat cell number and fat cell size in 10 fat depots were measured. Female baboons overfed as infants had markedly greater fat depot mass, primarily because of fat cell hypertrophy, than normally fed or underfed females. Overfed male baboons had a greater fat mass in 4 of 10 depots compared with males underfed or fed normally as infants. Underfeeding did not affect body weight, nor adipose mass of either sex. The results show that infant food intake does not have a major influence on the fat cell number of young adult baboons.
在狒狒身上检验了断奶前营养会影响成年脂肪细胞数量和肥胖程度这一假说。新生狒狒被喂食每100克配方奶热量密度分别为40.5千卡（喂食不足）、67.5千卡（正常喂食）和94.5千卡（喂食过量）的Similac配方奶。从断奶（16周）到5岁时进行尸检，所有狒狒都喂食相同的饮食。在尸检时，测量了10个脂肪储存部位的脂肪细胞数量和脂肪细胞大小。婴儿期喂食过量的雌性狒狒，主要由于脂肪细胞肥大，其脂肪储存部位的质量明显大于正常喂食或喂食不足的雌性狒狒。与婴儿期喂食不足或正常喂食的雄性狒狒相比，喂食过量的雄性狒狒在10个储存部位中的4个部位有更大的脂肪量。喂食不足对体重或两性的脂肪量均无影响。结果表明，婴儿期的食物摄入量对年轻成年狒狒的脂肪细胞数量没有重大影响。
