来自琉球叶底珠变种木材中的一叶萩生物碱。

Securinega alkaloids from the wood of Securinega suffruticosa var. amamiensis.

作者信息

Ohsaki Ayumi, Kobayashi Yukino, Yoneda Kaisuke, Kishida Akio, Ishiyama Haruaki

机构信息

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.

出版信息

J Nat Prod. 2007 Dec;70(12):2003-5. doi: 10.1021/np0780102. Epub 2007 Dec 1.

DOI:10.1021/np0780102

PMID:18052029

Abstract

Three new Securinega alkaloids, secu'amamines B-D ( 1- 3), were isolated from the wood of the Japanese medicinal plant Securinega suffruticosa var. amamiensis, together with five known analogues ( 4, 6- 9). The structures 1- 3 were elucidated by spectroscopic methods including 2D NMR, and all eight compounds were evaluated for cytotoxicity against two cancer cell lines.

摘要

从日本药用植物琉球叶底珠（Securinega suffruticosa var. amamiensis）的木材中分离出三种新的叶底珠生物碱，即叶底珠胺B-D（1-3），以及五种已知类似物（4、6-9）。通过包括二维核磁共振在内的光谱方法阐明了1-3的结构，并评估了所有八种化合物对两种癌细胞系的细胞毒性。