Ozeki A, Hitotsuyanagi Y, Hashimoto E, Itokawa H, Takeya K, de Mello Alves S
Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan.
J Nat Prod. 1998 Jun 26;61(6):776-80. doi: 10.1021/np980023f.
Four new quassinoids, cedronolactones A-D (1-4), together with nine known compounds, simalikalactone D (5), chaparrinone (6), chaparrin (7), glaucarubolone (8), glaucarubol (9), samaderine Z (10), guanepolide (11), ailanquassin A (12), and polyandrol (13), were isolated from the wood of Simaba cedron. The chemical structures of 1-4 were elucidated on the basis of their chemical and spectral properties. Cedronolactone A (1) was shown to exhibit a significant in vitro cytotoxicity (IC50 0.0074 microg/mL) against P-388 cells.
从锡马龙木中分离出了4个新的苦木素类化合物，即雪松内酯A - D（1 - 4），以及9个已知化合物，分别为西玛卡内酯D（5）、查帕里酮（6）、查帕林（7）、格劳卡鲁酮（8）、格劳卡鲁醇（9）、萨马德林Z（10）、胍内波苷（11）、阿兰苦木素A（12）和多雄甾醇（13）。根据化合物1 - 4的化学和光谱性质确定了其化学结构。雪松内酯A（1）对P - 388细胞显示出显著的体外细胞毒性（IC50为0.0074微克/毫升）。
