Simsek Serkan, Horzella Melanie, Kalesse Markus
Institut für Organische Chemie, Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany.
Org Lett. 2007 Dec 20;9(26):5637-9. doi: 10.1021/ol702640w. Epub 2007 Dec 4.
delta-Hydroxy-alpha,beta-unsaturated carbonyl compounds were prepared in one step via the vinylogous Mukaiyama aldol reactions with O,O-silyl ketene acetals. Isopropyl alcohol as additive and tryptophane-based B-phenyloxazaborolidinone were required for obtaining the gamma-alkylated product in high enantioselectivities.
通过与O，O-硅基乙烯酮缩醛发生插烯式向山羟醛反应一步制备δ-羟基-α，β-不饱和羰基化合物。为了以高对映选择性获得γ-烷基化产物，需要异丙醇作为添加剂和基于色氨酸的B-苯基恶唑硼烷酮。
