愈疮木苷元的形式合成。

A formal synthesis of the callipeltoside aglycone.

作者信息

Marshall James A, Eidam Patrick M

机构信息

Department of Chemistry, University of Virginia, PO Box 40019, Charlottesville, Virginia 22904, USA.

出版信息

Org Lett. 2008 Jan 3;10(1):93-6. doi: 10.1021/ol702024b. Epub 2007 Dec 5.

DOI:10.1021/ol702024b

PMID:18052287

Abstract

A synthesis of the macrocyclic core structure of callipeltoside A and a C9 epimer has been achieved by applications of chiral vinylzinc or Kishi-Nozaki-Hiyama (K-N-H) additions, Roskamp homologations, and acylketene or intramolecular K-N-H macrolactonizations as key bond-forming steps.

摘要

通过应用手性乙烯基锌或岸崎-野崎-日山（K-N-H）加成反应、罗斯坎普同系化反应以及酰基烯酮或分子内K-N-H大环内酯化反应作为关键的成键步骤，实现了卡里佩托苷A大环核心结构及其C9差向异构体的合成。