Ahlers S T, Thomas J R, Berkey D L
Behavioral Neuroscience Division, Naval Medical Research Institute, Bethesda, MD 20889-5055.
Physiol Behav. 1991 Nov;50(5):1013-8. doi: 10.1016/0031-9384(91)90430-v.
In order to study the effects of temperature changes induced by cold stress on working memory, telemetry thermistor probes were implanted into the hippocampal region of the brain and into the peritoneal cavity of rats. Temperatures in these regions were monitored while rats performed on a delayed matching-to-sample (DMTS) task at ambient temperatures of 23 degrees C and 2 degrees C. Matching accuracy was significantly decreased during exposure to 2 degrees C, indicating a marked impairment of short-term or working memory. Temperature in the hippocampus increased 2 degrees C during exposure to 23 degrees C, but only 1 degrees C when the environmental temperature was 2 degrees C. Body temperature showed a similar but less pronounced pattern in that cold exposure attenuated the increase in temperature observed when animals performed the DMTS task. These results suggest that cold-induced impairment of working memory may be associated with subtle temperature changes in the brain.
为了研究冷应激引起的温度变化对工作记忆的影响，将遥测热敏电阻探头植入大鼠的脑海马区和腹腔。在大鼠于23摄氏度和2摄氏度的环境温度下执行延迟匹配样本（DMTS）任务时，监测这些区域的温度。在暴露于2摄氏度期间，匹配准确性显著降低，表明短期或工作记忆明显受损。在暴露于23摄氏度期间，海马体温度升高2摄氏度，但当环境温度为2摄氏度时仅升高1摄氏度。体温呈现出类似但不太明显的模式，即冷暴露减弱了动物执行DMTS任务时观察到的温度升高。这些结果表明，冷诱导的工作记忆损伤可能与大脑中细微的温度变化有关。
