Corallo Carmela E, Ernest David
Pharmacy Department, Box Hill Hospital, Box Hill, VIC.
Crit Care Resusc. 2007 Dec;9(4):338-40.
Clozapine-induced neuroleptic malignant syndrome (NMS) may present differently from NMS associated with traditional antipsychotic agents, with fewer clinical features, particularly fewer extrapyramidal manifestations. The risk of developing NMS with clozapine does not appear dose-related. In half of cases, it occurs within 2 weeks of beginning clozapine therapy, but it can develop at any stage, especially with long-term use. We describe a patient who presented with atypical NMS after more than 10 years of clozapine treatment, and who was safely re-challenged with the same drug.
氯氮平所致的抗精神病药恶性综合征（NMS）可能与传统抗精神病药物相关的NMS表现不同，其临床特征较少，尤其是锥体外系表现较少。使用氯氮平发生NMS的风险似乎与剂量无关。在一半的病例中，它发生在开始氯氮平治疗的2周内，但也可能在任何阶段出现，尤其是长期使用时。我们描述了一名在接受氯氮平治疗10多年后出现非典型NMS的患者，该患者再次安全地接受了相同药物的治疗。
