DasGupta K, Young A
Department of Psychiatry, University of Wisconsin, Madison.
J Clin Psychiatry. 1991 Mar;52(3):105-7.
Neuroleptic malignant syndrome (NMS), a rare but serious side effect of psychotropic drugs, is usually attributed to blockade of striatal and hypothalamic dopaminergic tracts. Clozapine is an atypical antipsychotic that has minimal extrapyramidal effects and might not be expected to cause NMS. The authors report the development of NMS in a 30-year-old white man after three 25-mg clozapine doses. To their knowledge, this is the first case of NMS linked with clozapine in which concurrent psychotropic medications cannot be implicated.
抗精神病药恶性综合征（NMS）是一种罕见但严重的精神药物副作用，通常归因于纹状体和下丘脑多巴胺能通路的阻断。氯氮平是一种非典型抗精神病药物，其锥体外系反应极小，因此预计不会引起NMS。作者报告了一名30岁白人男性在服用三次25毫克氯氮平后发生NMS的情况。据他们所知，这是首例与氯氮平相关的NMS病例，且不存在同时使用其他精神药物的情况。
