Mueser K T, Douglas M S, Bellack A S, Morrison R L
Medical College of Pennsylvania-EPPI, Philadelphia 19129.
Schizophr Bull. 1991;17(4):565-82. doi: 10.1093/schbul/17.4.565.
The clinical importance of subtypes based on enduring deficit or negative symptoms was examined in a group of schizophrenic patients who were assessed twice over a 1-year period. Subgroups of patients with high levels of enduring negative or deficit symptoms, based on the Scale for the Assessment of Negative Symptoms and the Quality of Life Scale, had a poorer prognosis and were consistently worse in social adjustment, quality of life, and thought disorder over the year than were patients with less severe negative symptoms. Subtypes based on Andreasen's negative schizophrenia classification and on enduring thought disorder were only weakly related to other symptoms and social adjustment. Social-skill deficits were weakly related to the enduring negative symptom subtype and Andreasen's negative schizophrenia. The results suggest that enduring negative and deficit symptoms may be associated with a poor outcome in schizophrenia, including more severe positive symptoms, lower levels of social adjustment, and a poorer quality of life.
在一组精神分裂症患者中，研究了基于持续性缺陷或阴性症状的亚型的临床重要性，这些患者在1年时间内接受了两次评估。根据阴性症状评估量表和生活质量量表，具有高水平持续性阴性或缺陷症状的患者亚组预后较差，并且在这一年中，其社会适应、生活质量和思维紊乱方面始终比阴性症状较轻的患者更差。基于安德烈亚森阴性精神分裂症分类和持续性思维紊乱的亚型与其他症状和社会适应仅有微弱关联。社交技能缺陷与持续性阴性症状亚型和安德烈亚森阴性精神分裂症仅有微弱关联。结果表明，持续性阴性和缺陷症状可能与精神分裂症的不良预后相关，包括更严重的阳性症状、更低的社会适应水平和更差的生活质量。
