Cox B, Lomax P
Pharmacol Biochem Behav. 1976 Mar;4(3):263-7. doi: 10.1016/0091-3057(76)90239-2.
The seizure sensitive (WJL)UC) strain of Mongolian gerbils has been used to investigate the effects of drugs that modify central monoamine activity on spontaneous epileptiform seizures. Increasing central norepinephrine and dopamine levels significantly reduced the severity of the seizures and the importance of dopamine was further demonstrated by the protection from seizures after administration of the dopaminergic agonist apomorphine. These data indicate that a search for differences in regional levels, or turnover rates, of these amines between seizure sensitive and seizure resistant strains of gerbils might be profitable in determining the genetic deficit underlying the seizure phenomenon in these animals.
癫痫敏感型（WJL）UC品系的蒙古沙鼠已被用于研究改变中枢单胺活性的药物对自发性癫痫样发作的影响。提高中枢去甲肾上腺素和多巴胺水平可显著降低发作的严重程度，多巴胺能激动剂阿扑吗啡给药后对发作的保护作用进一步证明了多巴胺的重要性。这些数据表明，探寻癫痫敏感型和抗癫痫型沙鼠品系之间这些胺类物质在区域水平或周转率上的差异，可能有助于确定这些动物癫痫现象背后的遗传缺陷。
