Schonfeld A R, Glick S D
Pharmacol Biochem Behav. 1981 Apr;14(4):507-16. doi: 10.1016/0091-3057(81)90310-5.
The aim of this report was to examine the relationship between sensory-induced seizures, cerebral laterality (as measured by rotation) and nigrostriatal asymmetry in Mongolian gerbils. Seizure resistant gerbils made proportionally more spontaneous turns to be preferred direction than sensitive animals. Three prototypical antiepileptic drugs strongly elicited rotational behavior (carbamazepine (10-20 mg/kg), diazepam (16 mg/kg) and pentobarbital (40 mg/kg)) and two others (phenobarbital 20-40 mg/kg) and ethosuximide (500 mg/kg)) also appeared to potentiate rotation; only diphenylhydantoin and trimethadione were effective. Two dopaminergic agonists, amphetamine (4 mg/kg) and apomorphine (16 mg/kg) enhanced rotation at anticonvulsant doses while the dopaminergic antagonist haloperidol reduced rotational behavior at a dose (1 mg/kg) which exacerbate seizure severity. Finally, surgical induction of nigrostriatal asymmetry by means of unilateral electrolytic striatal lesions reduced seizure severity; sham and bilateral striatal lesions had no significant effects on seizures. These results suggest that seizure activity and rotational behavior are inversely related and, furthermore, that the link between these two behaviors may be the asymmetry between nigrostriatal dopaminergic systems.
本报告旨在研究蒙古沙鼠感觉诱发癫痫、大脑半球优势（通过旋转测量）与黑质纹状体不对称之间的关系。抗癫痫沙鼠比敏感动物更倾向于按比例做出更多转向偏好方向的自发转动。三种典型的抗癫痫药物强烈引发旋转行为（卡马西平（10 - 20毫克/千克）、地西泮（16毫克/千克）和戊巴比妥（40毫克/千克）），另外两种药物（苯巴比妥20 - 40毫克/千克和乙琥胺（500毫克/千克））似乎也增强了旋转；只有苯妥英和三甲双酮有效。两种多巴胺能激动剂，苯丙胺（4毫克/千克）和阿扑吗啡（16毫克/千克）在抗惊厥剂量下增强了旋转，而多巴胺能拮抗剂氟哌啶醇在剂量为1毫克/千克时降低了旋转行为，该剂量会加重癫痫严重程度。最后，通过单侧电解纹状体损伤手术诱导黑质纹状体不对称降低了癫痫严重程度；假手术和双侧纹状体损伤对癫痫没有显著影响。这些结果表明癫痫活动与旋转行为呈负相关，此外，这两种行为之间的联系可能是黑质纹状体多巴胺能系统之间的不对称。
