干扰素在髓样树突状细胞中的调控与功能
IFN regulation and functions in myeloid dendritic cells.
作者信息
Coccia Eliana Marina
机构信息
Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
出版信息
Cytokine Growth Factor Rev. 2008 Feb;19(1):21-32. doi: 10.1016/j.cytogfr.2007.10.005. Epub 2007 Dec 3.
A central issue in dendritic cells (DC) biology is to understand how type I IFNs modulate the immuno-regulatory properties of DC. In this review I will address this issue in light of the recent experimental evidence on the expression and function of these cytokines in myeloid DC. This knowledge may have important therapeutic implications in infectious and neoplastic diseases and open new perspectives in the use of IFNs as vaccine adjuvants and in the development of DC-based vaccines.
树突状细胞（DC）生物学中的一个核心问题是了解I型干扰素如何调节DC的免疫调节特性。在这篇综述中，我将根据最近关于这些细胞因子在髓样DC中的表达和功能的实验证据来探讨这个问题。这些知识可能在感染性疾病和肿瘤性疾病中具有重要的治疗意义，并为干扰素作为疫苗佐剂的使用以及基于DC的疫苗的开发开辟新的前景。
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