De Weerdt Annick, Claeys Kristl G, De Jonghe Peter, Ysebaert Dirk, Chapelle Thiery, Roeyen Geert, Jorens Philippe G
Department of Critical Care Medicine, University Hospital of Antwerp, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium.
Clin Neurol Neurosurg. 2008 Mar;110(3):291-4. doi: 10.1016/j.clineuro.2007.10.014. Epub 2007 Dec 4.
Patients, in particular recipients of orthotopic liver transplants, receiving the immunosuppressant tacrolimus (FK-506), are at risk for developing central neurotoxic adverse events. We report the occurrence of a tacrolimus-induced peripheral neurotoxic event, i.e. pure motor axonal polyneuropathy of the lower limbs in a 44-year-old woman, 9 days after combined orthotopic liver and pancreas transplantation. She was treated for 5 days with intravenous immunoglobulins. Partial recovery followed over months to years. An overview of all 11 reported FK506-associated polyneuropathies is given.
患者，尤其是原位肝移植受者，在接受免疫抑制剂他克莫司（FK - 506）治疗时，有发生中枢神经毒性不良事件的风险。我们报告了1例他克莫司诱发的外周神经毒性事件，即1名44岁女性在原位肝胰联合移植术后9天出现下肢纯运动性轴索性多发性神经病。她接受了5天的静脉注射免疫球蛋白治疗。数月至数年之后部分恢复。本文还对已报道的11例与FK506相关的多发性神经病进行了概述。
