Bhagavati S, Maccabee P, Muntean E, Sumrani N B
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA.
Transplant Proc. 2007 Dec;39(10):3465-7. doi: 10.1016/j.transproceed.2007.06.088.
Tacrolimus is used widely for immunosuppression following transplantation. It has rarely been linked to the development of peripheral neuropathy. However, one study also reported improvement in peripheral neuropathy after tacrolimus use. We have reported herein two patients who developed chronic sensorimotor polyneuropathy after tacrolimus use following renal transplantation. One patient had an unusual presentation with bilateral facial and extremity weakness and a relapsing course. The other patient presented with focal sensory symptoms in one hand. Electrophysiological studies confirmed widespread, predominantly demyelinating or axonal polyneuropathy. We concluded that patients on tacrolimus should be carefully monitored for symptoms suggestive of peripheral neuropathy.
他克莫司广泛用于移植后的免疫抑制。它很少与周围神经病变的发生有关。然而，一项研究也报告了使用他克莫司后周围神经病变有所改善。我们在此报告了两名肾移植后使用他克莫司后发生慢性感觉运动性多神经病变的患者。一名患者表现异常，出现双侧面部和肢体无力且病程呈复发型。另一名患者表现为单手的局灶性感觉症状。电生理研究证实存在广泛的、以脱髓鞘或轴索性为主的多神经病变。我们得出结论，应对使用他克莫司的患者仔细监测是否有提示周围神经病变的症状。
