Pinto A S, Ferreira W F, Costa C, Silva A P, Alvarez E P, Sousa R A, Mansinho K, Champalimaud J L, Araújo C, Dias F
Instituto de Higiene e Medicina Tropical, Laboratório de Imunologia, I.P.O.F.G., Lisboa.
Acta Med Port. 1991 Dec;4 Suppl 1:64S-66S.
In the geographic distribution of HIV-2, it is known that this infection is most prevalent in West Africa. Since 1986 we have studied seropositive and seronegative clusters, in Guinea-Bissau with follow-ups in 1988, 1989, 1990 and 1991. Analysis of the results show the high incidence of this infection. 8.51% of the 4,372 people of the general population studied were seropositive, showing the high predominance of HIV-2 infection. Only 4 cases were exclusively reactive to HIV-1 and a slow evolution of HIV-1 infections. In the seroconversions of HIV-2 infections the antibodies appeared first to the core components and secondly to the surface glycoproteins. Some of the laboratory parameters affected in the evolution of the infection include a gradual increase in immunoglobulins and a decrease in CD4 lymphocytes and in the CD4/CD8 ratio. A comparison of these variations in HIV-2 infected people, with or without cross-reactivity to HIV-1, reveals that they are much more evident in exclusively HIV-2 positive people. This fact can indicate that the variants responsible for the cross-reactions are less pathogenic and phylogenetically less developed.
在HIV-2的地理分布方面，已知这种感染在西非最为普遍。自1986年以来，我们在几内亚比绍对血清阳性和血清阴性群体进行了研究，并在1988年、1989年、1990年和1991年进行了随访。结果分析显示了这种感染的高发病率。在接受研究的4372名普通人群中，8.51%呈血清阳性，表明HIV-2感染占主导地位。只有4例仅对HIV-1呈反应性，且HIV-1感染进展缓慢。在HIV-2感染的血清转化过程中，抗体首先出现在核心成分上，其次出现在表面糖蛋白上。感染进展过程中受影响的一些实验室参数包括免疫球蛋白逐渐增加、CD4淋巴细胞及CD4/CD8比值降低。对这些在HIV-2感染者中有无与HIV-1交叉反应的变化进行比较发现，它们在仅HIV-2阳性的人群中更为明显。这一事实可能表明，引起交叉反应的变体致病性较低且在系统发育上较不发达。
