Zaidi Neeha, Nixon Alan J
Comparative Orthopaedics Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
Ann N Y Acad Sci. 2007 Nov;1117:62-72. doi: 10.1196/annals.1402.074.
Stem cells of various origins, particularly endothelial progenitor cells (EPCs), have potential to enhance bone repair and regeneration. EPCs are resident in the bone marrow and home to ischemic sites to initiate vasculogenesis. Although it was previously believed that only local endothelial cells arrive at ischemic sites, new evidence suggests that EPCs are recruited from the periphery. This finding has a considerable array of therapeutic implications. For example, administered EPCs can localize to sites of osteogenesis where they increase blood vessel formation; this may be useful in enhancing fracture repair.
各种来源的干细胞，尤其是内皮祖细胞（EPCs），具有促进骨修复和再生的潜力。EPCs存在于骨髓中，并归巢至缺血部位以启动血管生成。尽管此前认为只有局部内皮细胞会到达缺血部位，但新证据表明EPCs是从外周募集而来的。这一发现具有一系列重要的治疗意义。例如，注入的EPCs可定位于成骨部位，在那里它们可增加血管形成；这可能有助于增强骨折修复。
