Bondarenko Gennadiy I, Burleigh David W, Durning Maureen, Breburda Edith E, Grendell Richard L, Golos Thaddeus G
Wisconsin National Primate Research Center and Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison 53715, USA.
J Immunol. 2007 Dec 15;179(12):8042-50. doi: 10.4049/jimmunol.179.12.8042.
The unique MHC phenotype of the human and nonhuman primate placenta has suggested a potential role in maternal-fetal immune tolerance, pregnancy success, and maternal as well as fetal well-being. In the rhesus monkey (Macaca mulatta) a nonclassical MHC class I molecule, Mamu-AG, is a putative homologue of HLA-G and is hypothesized to play a role in maternal-fetal immune interactions during pregnancy. Rhesus monkeys were passively immunized during the second week after implantation with a mAb against Mamu-AG. Passive immunization altered the growth and vascularization of the fetal placenta, the placental modification of maternal endometrial vessels, the maternal leukocyte response to implantation, and the differentiation of epithelial and stromal cells in the endometrium. These data are the first to demonstrate in vivo the importance of MHC class I molecules expressed on primate trophoblasts in establishing an important environment for pregnancy success through coordinated interactions between endometrial and fetal tissues.
人类和非人类灵长类动物胎盘独特的主要组织相容性复合体（MHC）表型表明，其在母胎免疫耐受、妊娠成功以及母体和胎儿健康方面可能发挥作用。在恒河猴（猕猴）中，一种非经典的MHC I类分子Mamu-AG被认为是HLA-G的同源物，并被假定在妊娠期间的母胎免疫相互作用中发挥作用。在植入后第二周，用抗Mamu-AG单克隆抗体对恒河猴进行被动免疫。被动免疫改变了胎儿胎盘的生长和血管形成、母体子宫内膜血管的胎盘修饰、母体白细胞对植入的反应以及子宫内膜中上皮细胞和基质细胞的分化。这些数据首次在体内证明了灵长类滋养层细胞上表达的MHC I类分子通过子宫内膜和胎儿组织之间的协调相互作用，为妊娠成功建立重要环境的重要性。
