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结构同种异体骨在严重胫骨骨丢失膝关节翻修全膝关节置换术中的应用。

Use of structural allograft in revision total knee arthroplasty in knees with severe tibial bone loss.

作者信息

Engh Gerard A, Ammeen Deborah J

机构信息

Anderson Orthopaedic Research Institute, 2501 Parker's Lane, Suite 200, Alexandria, VA 22306, USA.

出版信息

J Bone Joint Surg Am. 2007 Dec;89(12):2640-7. doi: 10.2106/JBJS.F.00865.

Abstract

BACKGROUND

Tibial bone loss is frequently encountered at the time of revision total knee arthroplasty, and the outcome of the revision often depends on the management of this bone deficiency. We examined the clinical and radiographic outcomes of a series of revision total knee arthroplasties in which a structural allograft had been used to reconstruct a tibial bone defect encountered at the time of the revision procedure.

METHODS

From January 1985 through September 1999, one surgeon performed revision arthroplasty in forty-nine knees (forty-seven patients) with a severe tibial bone defect. The reasons for the revisions included polyethylene wear and osteolysis in twenty-four knees, aseptic loosening in seventeen knees, infection in five knees, and failure for another reason for three knees. Structural allograft was used alone in thirty-five knees and in conjunction with a tibial augment in fourteen knees. The mean age of the patients at the time of the revision arthroplasty with the allograft was sixty-seven years. The patients were assessed clinically with use of the Knee Society score and radiographically.

RESULTS

The status of the implant was known for forty-six of the forty-nine knees in this study. It was unknown for one patient (one knee) who was lost to follow-up and for two patients (two knees) who died less than five years postoperatively. Four revision procedures in four patients failed and required a reoperation. Two of the failures were due to infection. At a mean of ninety-seven months postoperatively, the mean Knee Society clinical score was 84 points for the knees that had not had a reoperation due to failure. The mean arc of motion improved from 87 degrees preoperatively to 103 degrees at the most recent follow-up evaluation. Histological evaluation of specimens retrieved at two autopsies demonstrated graft union to host bone.

CONCLUSIONS

A structural allograft provides a stable and durable reconstruction of a tibial bone deficiency. At a mean of ninety-five months postoperatively, we found no instance of graft collapse or aseptic loosening associated with the structural allograft. We recommend the use of a structural allograft for the management of severe tibial bone deficiency at the time of revision total knee arthroplasty.

摘要

背景

翻修全膝关节置换术时经常会遇到胫骨骨量丢失的情况,而翻修手术的结果往往取决于对这种骨缺损的处理。我们研究了一系列翻修全膝关节置换术的临床和影像学结果,这些手术中使用了结构性同种异体骨移植来重建翻修手术时遇到的胫骨骨缺损。

方法

从1985年1月至1999年9月,一名外科医生对49例膝关节(47例患者)进行了翻修手术,这些膝关节存在严重的胫骨骨缺损。翻修的原因包括24例膝关节的聚乙烯磨损和骨溶解、17例膝关节的无菌性松动、5例膝关节的感染以及3例膝关节因其他原因失败。35例膝关节单独使用结构性同种异体骨移植,14例膝关节联合使用胫骨增强装置。接受同种异体骨移植翻修手术时患者的平均年龄为67岁。使用膝关节协会评分对患者进行临床评估,并进行影像学检查。

结果

本研究中49例膝关节中有46例的植入物情况已知。1例患者(1例膝关节)失访,2例患者(2例膝关节)术后不到5年死亡,这3例的情况未知。4例患者的4次翻修手术失败,需要再次手术。其中2例失败是由于感染。术后平均97个月时,因失败未再次手术的膝关节的膝关节协会临床评分平均为84分。平均活动弧度从术前的87度改善到最近一次随访评估时的103度。在两次尸检中获取的标本的组织学评估显示移植物与宿主骨愈合。

结论

结构性同种异体骨移植可为胫骨骨缺损提供稳定且持久的重建。术后平均95个月时,我们未发现与结构性同种异体骨移植相关的移植物塌陷或无菌性松动情况。我们建议在翻修全膝关节置换术时使用结构性同种异体骨移植来处理严重的胫骨骨缺损。

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