Kavookjian Jan, Elswick Betsy M, Whetsel Tara
The Department of Pharmacy Care Systems, Harrison School of Pharmacy, Auburn, Alabama (Dr Kavookjian)
The Clinical Pharmacy Department, West Virginia University School of Pharmacy, Morgantown (Dr Elswick, Dr Whetsel)
Diabetes Educ. 2007 Nov-Dec;33(6):962-88; discussion 989-90. doi: 10.1177/0145721707308411.
The purpose of this systematic review is to assess and summarize evidence and gaps in the literature regarding the intervention for being active (exercise) among individuals with diabetes.
Twelve electronic databases were searched. Publications eligible for inclusion specifically studied learning, behavioral, clinical, and humanistic outcomes for exercise interventions in adult patients with type 1 and type 2 diabetes.
Seven reviews (2 systematic reviews, 3 meta-analyses, 2 technical reviews) and 34 individual, nonreview studies (18 randomized controlled trials, 16 nonrandomized trials) met inclusion criteria. For type 2 diabetes, findings suggested that exercise had a positive effect on glycemic control and decreased cardiovascular risk, but the impact of exercise on behavioral and humanistic outcomes was unclear; long-term outcomes and adherence to exercise interventions is unknown because most studies were of short duration. The overall impact of varied types of exercise in type 1 diabetes was unclear, especially regarding glycemic control. Potential benefits of exercise in type 1 may include improved cardiovascular health.
The review did not identify specific successful intervention details because of the heterogeneity of studies, subjects, and research gaps. General findings suggest that physical activity is better than no exercise at all; intensive regimens, if tolerated by patients, achieved better clinical outcomes than less intensive regimens. Reviewed studies using structured exercise regimens exhibited a more significant impact on outcomes. Substantial gaps in the literature include studies measuring direct effects of exercise in the US minority populations most affected by type 2 diabetes and economic evaluations of exercise interventions. Interventions must be tailored to individual patient needs to succeed.
本系统评价旨在评估和总结关于糖尿病患者积极参与(运动)干预的文献中的证据和差距。
检索了12个电子数据库。符合纳入标准的出版物专门研究了1型和2型糖尿病成年患者运动干预的学习、行为、临床和人文结局。
7篇综述(2篇系统评价、3篇荟萃分析、2篇技术综述)和34项非综述性单项研究(18项随机对照试验、16项非随机试验)符合纳入标准。对于2型糖尿病,研究结果表明运动对血糖控制有积极影响,并降低心血管风险,但运动对行为和人文结局的影响尚不清楚;由于大多数研究持续时间较短,运动干预的长期结局和依从性未知。1型糖尿病中不同类型运动的总体影响尚不清楚,尤其是在血糖控制方面。1型糖尿病运动的潜在益处可能包括改善心血管健康。
由于研究、受试者的异质性和研究差距,该评价未确定具体成功干预细节。总体研究结果表明,身体活动总比完全不运动要好;如果患者能够耐受,强化方案比低强度方案能取得更好的临床结局。使用结构化运动方案的综述性研究对结局的影响更为显著。文献中的重大差距包括对受2型糖尿病影响最大的美国少数族裔人群运动直接影响的测量研究以及运动干预的经济评估。干预措施必须根据个体患者的需求进行调整才能取得成功。