Müntzing J, Williams P D, Murphy G P
Res Commun Chem Pathol Pharmacol. 1976 Mar;13(3):541-50.
Wistar-Furth rats and BALB/c mice were implanted with tumor cells from metastases or primaries of an experimental Wilms' tumor or an experimental renal cell adenocarcinoma. The survival time, metastasis formation and growth of the primary tumor after implantation of metastatic tumor cells did not exceed those found after implantation of tumor cells from the tumor primaries. It is concluded that the higher growth rate usually found in metastases is not necessarily due to a selection of metastatic cells with a short cell growth cycle but that there are other environmental factors enhancing the growth of metastases.
将来自实验性肾母细胞瘤或实验性肾细胞腺癌转移灶或原发灶的肿瘤细胞植入Wistar-Furth大鼠和BALB/c小鼠体内。植入转移瘤细胞后，其生存时间、转移形成情况以及原发肿瘤的生长均未超过植入肿瘤原发灶的肿瘤细胞后的相应情况。由此得出结论，转移灶中通常较高的生长速率不一定是由于选择了细胞生长周期短的转移细胞，而是存在其他促进转移灶生长的环境因素。
