Murphy G P, Williams P D, Klein R
Res Commun Chem Pathol Pharmacol. 1975 Oct;12(2):397-404.
Growth characteristics, metastatic spread, and survival times were evaluated in a transplantable Wistar/Furth rat Wilms' tumor model. Tumor suspensions of various tumor cell dosages were injected in an attempt to find the optimum level of tumor take. Lung metastases were frequent following tumor injection by all routes. However, tumor spread to the lungs was the least frequent following subcutaneous (SC) injection of the tumor. Survival time for the intramuscular (IM) group was statistically longer at all tumor dose levels. For the 1 X 10(5) tumor dosage, survival time ranged from a mean of 27 days for the intrarenal (IR) group to a mean 42 days for the IM group. For the 1 X 10(4) dosage, survival time ranged from a mean of 37 days for the intraperitoneal (IP) group to a mean of 51 days for the IM group. It is concluded that this animal tumor closely resembles the human Wilms' tumor, and that the point at which the transplanted tumor fails to be successfully transplanted is below the dosage level of 1 X 10(3) tumor cells.
在可移植的Wistar/Furth大鼠肾母细胞瘤模型中评估生长特征、转移扩散和生存时间。注射不同肿瘤细胞剂量的肿瘤悬液，试图找到肿瘤接种的最佳水平。通过所有途径注射肿瘤后，肺转移都很常见。然而，皮下（SC）注射肿瘤后，肿瘤扩散到肺部的情况最少见。在所有肿瘤剂量水平下，肌肉注射（IM）组的生存时间在统计学上更长。对于1×10⁵的肿瘤剂量，肾内（IR）组的平均生存时间为27天，而IM组为42天。对于1×10⁴的剂量，腹腔内（IP）组的平均生存时间为37天，而IM组为51天。结论是，这种动物肿瘤与人类肾母细胞瘤非常相似，并且移植肿瘤未能成功移植的点低于1×10³肿瘤细胞的剂量水平。
