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[甲状旁腺与骨骼。血液透析患者甲状旁腺功能的管理及骨代谢评估]

[Parathyroid and bone. Management of parathyroid function and evaluation of bone metabolism in hemodialysis patients].

作者信息

Goto Shunsuke, Fukagawa Masafumi

机构信息

Kobe University School of Medicine, Division of Nephrology and Kidney Center.

出版信息

Clin Calcium. 2007 Dec;17(12):1830-4.

Abstract

Disturbances in mineral and bone metabolism due to loss of kidney function greatly influence morbidity and quality of life, so Kidney Disease: Improving Global Outcomes (KDIGO) proposed the concept of chronic kidney disease-mineral and bone disorder (CKD-MBD). Japanese Society for Dialysis Therapy has created guidelines for the management of secondary hyperparathyroidism associated prognosis in hemodialysis patients, and we are managing parathyroid function of hemodialysis patients under this guideline. Bone biopsy is not recommended as part of routine evaluation for CKD-MBD because bone biopsy is the invasive examination. KDIGO proposed new histological classification of renal osteodystrophy, TMV classification, for standardizing a result of bone histomorphometry. We expect that new guideline improve the prognosis of hemodialysis patients.

摘要

肾功能丧失引起的矿物质和骨代谢紊乱极大地影响发病率和生活质量,因此改善全球肾脏病预后组织(KDIGO)提出了慢性肾脏病 - 矿物质和骨异常(CKD - MBD)的概念。日本透析治疗学会制定了血液透析患者继发性甲状旁腺功能亢进相关预后管理指南,我们正在该指南下管理血液透析患者的甲状旁腺功能。由于骨活检是一种侵入性检查,不建议将其作为CKD - MBD常规评估的一部分。KDIGO提出了肾性骨营养不良的新组织学分类——TMV分类,以规范骨组织形态计量学结果。我们期望新指南能改善血液透析患者的预后。

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