Laros C D, Kuyper C M
Respiration. 1976;33(5):325-48. doi: 10.1159/000193748.
The most important primary cause of generalized pulmonary emphysema is in all probability the loss of mechanical stability of the connective tissue framework in the lung parenchyma. The complexity of the interrelations and interdependencies between the fibres and the ground substance, leads to the mapping out of a more detailed outline of the vulnerable parts in a similar framework. It is concluded that the junctions especially constitute weak spots. Glycosaminoglycans, glycoproteins and proteoglycans particularly hold a key position as cementing substances. The importance of female sex hormones in the metabolism of the ground substance is indicated. A survey is given of the possible threats to a similar system. An attempt is made to disentangle the multitude of possible pathogenetic pathways which lead to emphysematous disintegration. Perspectives of future emphysema research are discussed on the basis of these considerations. Preventive, protective, and reconstructive measures are proposed.
泛发性肺气肿最重要的原发性病因很可能是肺实质结缔组织框架机械稳定性的丧失。纤维与基质之间相互关系和相互依存性的复杂性，促使人们勾勒出类似框架中易损部位更详细的轮廓。得出的结论是，连接处尤其构成薄弱点。糖胺聚糖、糖蛋白和蛋白聚糖作为黏合物质特别占据关键地位。表明了女性性激素在基质代谢中的重要性。概述了对类似系统可能的威胁。试图理清导致肺气肿性崩解的众多可能的致病途径。基于这些考虑讨论了未来肺气肿研究的前景。提出了预防、保护和重建措施。
